A promising range of applications has shown up in this week’s up-and-comers list, including what may be a popular new genre of game — health care.

For those who haven’t been following recently, this list is derived by looking at the apps on AppData with between 100,000 and 1 million users, that grew by the most monthly active users in the last week. Inevitably, some apps seen here are simple quizzes or gift-giving types, that have short and uninteresting life-spans. However, this list also provides an early look at high-quality apps that go on to become major hits — like LOLapps‘ string of role-playing games released in recent weeks, including Champions Online Diva Life, Yakuza Lords, and more.

	Name	MAU	Gain	Gain, %
1.	Medical Mayhem	444,487	+444,186	+99.93
2.	Band of Heroes	881,360	+191,253	+21.70
3.	The Hierarchy	550,764	+187,483	+34.04
4.	Piou Piou contre les cactus	540,930	+179,711	+33.22
5.	Ask a Friend	522,568	+171,577	+32.83
6.	魔力學堂Web	178,394	+109,746	+61.52
7.	Ninja Warz	188,815	+81,698	+43.27
8.	Ponzi, Inc.	127,113	+80,217	+63.11
9.	COLLAPSE!	331,537	+76,232	+22.99
10.	Top Fish	169,967	+65,778	+38.70
11.	GooBox – Giochi gratuiti	109,688	+57,820	+52.71
12.	BlingTown	160,758	+57,721	+35.91
13.	WHAT IS YOUR PURPOSE IN LIFE?	411,929	+45,216	+10.98
14.	Santa Yourself	102,230	+41,619	+40.71
15.	Do you think…?	372,339	+40,233	+10.81
16.	The True Age Test	426,093	+36,342	+8.53
17.	Spore Islands	154,986	+34,839	+22.48
18.	Which Classic Hollywood Actress Are You?	204,907	+32,178	+15.70
19.	Gift Creator	636,920	+31,986	+5.02
20.	Flowers 4 You!!	407,637	+30,499	+7.48

So today, at number one on the list, we have Ultimate Slot Machines, a game made by Hong Kong-based 6 Waves — or we would have it if the developer had designated it as a “game” within Facebook’s application directory, instead of putting it in the “lifestyle” category. Anyway, in it, you can choose from all sorts of slot machine games like what you’d see in a casino, except you can’t win real money. The game has gone from 0 to 484,000 within the last week, probably partially due to developer cross-promoting it across its dozens of other apps.

In second place — but first on this list — we have Medical Mayhem, made by a little-known developer called Vojo World. Interestingly, the game is being cross-promoted by 6 Waves within the toolbar it runs on various apps. And, similar to Ultimate Slot Machines, this app has grown nearly all of it 444,000 monthly active users within the past week. We’re also interested to see how the medical genre does on Facebook — especially, for American audiences, as Congress debates a major overhaul of the real-life health care system. This game makes you the boss of a hospital (we presume a private hospital, not a government-run one), and tasks you with organizing doctors and nurses to take care of patients as quickly and effectively as possible.

LOLapps has one RPG still on this list, that is close to graduation — Band of Heroes, with 191,000 new users and 881,000 total monthly actives. We expect it to have moved up into the big leagues of apps with more than 1 million users by this time next week.

Some other, previously-seen games on today’s list are spy RPG The Hierarchy, from Serious Business. It grew by 187,000 to reach 551,000 monthly actives. Other returns are Ponzi, Inc., a corporate business RPG, Top Fish from Slide, arcade-style game COLLAPSE! and Electronic Art’s Spore Islands.

Also notable are two French games, Piou Piou contre les cactus and GooBox – Giochi gratuiti, both of which have also made this list before.